Description
Product Description
I-Nem Injection contains a combination of Imipenem and Cilastatin Sodium, which belongs to the class of carbapenem antibiotics. It is used for the treatment of severe bacterial infections caused by susceptible organisms, including infections of the respiratory tract, urinary tract, skin, soft tissue, bones, joints, abdomen, and the female reproductive system.
Imipenem is a broad-spectrum beta-lactam antibiotic that kills bacteria by inhibiting cell wall synthesis. Cilastatin is an enzyme inhibitor that prevents the breakdown of imipenem in the kidneys, ensuring higher and sustained antibiotic levels in the body for effective infection control.
I-Nem Injection is administered intravenously (IV) under the supervision of a qualified healthcare professional. It should not be self-administered.
Product Specification
| Parameter | Specification |
|---|---|
| Brand Name | I-Nem Injection |
| Generic Name | Imipenem and Cilastatin Injection IP |
| Composition | Each vial contains: Imipenem IP 500 mg + Cilastatin Sodium IP 500 mg (or as specified) |
| Strength | 500 mg + 500 mg per vial |
| Dosage Form | Powder for Injection |
| Route of Administration | Intravenous (IV) infusion / injection |
| Indications / Uses | Treatment of severe bacterial infections such as lower respiratory tract infections, urinary tract infections, intra-abdominal infections, gynecological infections, septicemia, bone and joint infections, and skin/soft tissue infections |
| Mechanism of Action | Imipenem inhibits bacterial cell wall synthesis; Cilastatin prevents renal degradation of Imipenem, enhancing its efficacy |
| Packaging Type | Vial with sterile diluent (if applicable) |
| Pack Size | Single vial (or pack of 1’s / 10’s as per manufacturer) |
| Manufacturer / Marketer | [Insert Manufacturer / Marketing Company Name] |
| Shelf Life | 24 Months (typical) |
| Storage Conditions | Store below 25°C. Protect from light and moisture. Reconstituted solution should be used immediately or as per label instructions |
| Prescription Type | Schedule H1 Drug – To be sold by retail on the prescription of a registered medical practitioner only |
| Common Side Effects | Nausea, vomiting, diarrhea, rash, injection site pain |
| Serious Side Effects | Allergic reactions, seizures, liver enzyme elevation (rare) |
| Precautions | Use with caution in patients with renal impairment or history of seizures; not recommended during pregnancy unless prescribed by physician |
| Drug Interactions | May interact with valproic acid, ganciclovir, probenecid, and other antibiotics |
| Reconstitution | Reconstitute the powder with suitable diluent (e.g., sterile water for injection or 0.9% sodium chloride solution) as per manufacturer’s instructions |
| Mode of Administration | Administer slowly by IV infusion over 20–30 minutes under medical supervision |
| Storage & Handling | Keep out of reach of children. Use aseptic techniques during preparation and administration |
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