Description
Product Description
Xylistin 1 MIU Injection contains Colistimethate Sodium (1 Million International Units), a polymyxin-class antibiotic used for treating severe bacterial infections caused by multidrug-resistant Gram-negative organisms, such as Pseudomonas aeruginosa, Acinetobacter baumannii, and Klebsiella pneumoniae.
It is indicated for hospital-acquired pneumonia, bloodstream infections, urinary tract infections, intra-abdominal infections, and meningitis caused by susceptible bacteria.
Xylistin is available as a sterile powder for injection, which must be reconstituted with an appropriate diluent before intravenous or intramuscular administration. The product is intended for use under the supervision of a qualified healthcare professional.
Store below 25°C, protect from light and moisture, and use the reconstituted solution immediately or as directed on the label.
Product Specification
| Parameter | Specification |
|---|---|
| Brand Name | Xylistin 1 MIU Injection |
| Generic Name | Colistimethate Sodium Injection IP |
| Strength | 1 Million International Units (1 MIU) |
| Composition | Each vial contains: Colistimethate Sodium IP equivalent to 1 Million IU of Colistin Base Activity |
| Dosage Form | Sterile Powder for Injection |
| Route of Administration | Intravenous (IV) or Intramuscular (IM) use |
| Indications / Uses | Treatment of serious infections caused by multidrug-resistant Gram-negative bacteria (e.g., Pseudomonas aeruginosa, Acinetobacter, Klebsiella spp.) |
| Mechanism of Action | Colistimethate Sodium interacts with bacterial cell membranes, increasing permeability and leading to cell death |
| Packaging Type | Glass vial (with sterile diluent if applicable) |
| Pack Size | Single vial (1 MIU) |
| Manufacturer / Marketer | Cipla Ltd. |
| Shelf Life | 24 Months (Typical) |
| Storage Conditions | Store below 25°C. Protect from moisture and light. Reconstituted solution should be used immediately or as per manufacturer’s instruction |
| Prescription Type | Schedule H1 Drug – To be sold by retail on the prescription of a registered medical practitioner only |
| Common Side Effects | Pain at injection site, tingling sensation, dizziness, mild kidney effects |
| Serious Side Effects | Nephrotoxicity, neurotoxicity, muscle weakness (rare, dose-related) |
| Precautions | Use with caution in patients with renal impairment or neuromuscular disorders. Dose adjustment may be required |
| Drug Interactions | May increase toxicity when used with other nephrotoxic or neurotoxic agents (e.g., aminoglycosides, vancomycin) |
| Reconstitution | Reconstitute with sterile water for injection or 0.9% sodium chloride solution before use |
| Mode of Administration | Administer slowly by IV infusion or deep IM injection under medical supervision |
| Storage & Handling | Keep out of reach of children. Handle aseptically during preparation and administration |
Reviews
There are no reviews yet.